AREDS II Eye Study Addresses Beta-Carotene Problems

By Teri Farley


Age-Related Eye Disease Study 2 or AREDS II is a study of how nutrients can affect the eyesight. The first study, conducted in 2001, had shown that a high level of antioxidants could reduce the risk of blindness up to 25 percent. However, there were problems with the formulation and the second study effectively addressed these issues.

People with eye disease have said that it is very debilitating. This affects nearly a million people, around 90% elderly, in the United States. People can develop eye disease in several ways. Some are born blind because of defects during the pregnancy. Others go blind after injury or due to diabetes complications. The majority of people that are blind have suffered cataracts or age-related macular degeneration (AMD), which is an aging disease.

There are some treatments available today, but most of them work only for a certain segment of affected people. Many people have used laser surgery and it has been found to be very effective. However, it is expensive and has side effects that could actually worsen sight. Side effects from laser surgery are not uncommon, although they are rarely severe. Still, they can cause you to lose your peripheral vision, can worsen your visual acuity, can reduce your night vision, or can even cause hemorrhaging.

AREDS, the initial Age-Related Eye Disease Study was finished and released in 2001. This study was begun to review risk factors and history associated with cataracts and AMD. Another purpose was to analyze whether higher doses of antioxidants might affect AMD or cataracts. They looked at a combination of vitamin C, vitamin E, zinc, and beta-carotene.

In the first study, the researchers found that a high level of antioxidants could reduce the possibility of blindness in high risk individuals by about 25 percent. High risk individuals were those who either already had intermediate AMD or AMD in only one of their eyes. However, one ingredient of the original formula was beta-carotene, which has been linked to an increase in risk of lung cancer for smokers. Additionally, there was no effect on cataracts.

In May 2013, the results of the second study were released. One research goal of this study was to determine whether there was a good substitute for the beta-carotene that was used for the initial formula. Researchers found that two antioxidants, zeaxanthin and lutein, were effective substitutes for the beta-carotene and did not reduce the effectiveness. This is important news for high risk AMD individuals who are interested in trying this formula.

A lot of the elderly are already on various prescriptions. In addition to this they may use over-the-counter drugs or supplements. The high-dose supplements in this combination could interfere or cause some of these medications to lose their effectiveness.

Laser surgery has some great effects but it is expensive and it can have serious complications. The initial formula discovered in the AREDS II may be a safer alternative to surgery. This study has confirmed that the formula of antioxidants and zinc reduce AMD risk. Furthermore, the study revealed that lutein and zeaxanthin were effective substitutes for beta-carotene. Before using any new medication please be sure to speak to your doctor.




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